Thyroid-Specific Transcription Factors.
نویسندگان
چکیده
منابع مشابه
Thyroid-Specific Transcription Factors and Their Roles in Thyroid Cancer
Homeodomain, forkhead domain, and paired domain-containing transcription factors play a major role in development, tissue-specific gene expression, and tissue homeostasis in organs where they are expressed. Recently, their roles in stem cell and cancer biology are emerging. In the thyroid, NKX2-1, FOXE1, and PAX8 transcription factors are responsible for thyroid organogenesis and expression of ...
متن کاملThyroid-specific transcription factors control Hex promoter activity.
The homeobox-containing gene Hex is expressed in several cell types, including thyroid follicular cells, in which it regulates the transcription of tissue- specific genes. In this study the regulation of Hex promoter activity was investigated. Using co- transfection experiments, we demonstrated that the transcriptional activity of the Hex gene promoter in rat thyroid FRTL-5 cells is approximate...
متن کاملExpression of Thyroid-specific Transcription Factors TTF-1 and PAX-8 in Human Thyroid Neoplasms1
TTF-1 and PAX-8 are tissue-specific transcription factors expressed in the thyroid follicular cells, contributing to the maintenance of the differ entiated phenotype. In fact, it has been demonstrated that TTF-1 and PAX-S are able to activate transcription from thyroglobulin and thyroperoxidase (TPO) promoters, the transcriptional activity of which is in vivo restricted only to the thyroid foll...
متن کاملExpression of thyroid-specific transcription factors TTF-1 and PAX-8 in human thyroid neoplasms.
TTF-1 and PAX-8 are tissue-specific transcription factors expressed in the thyroid follicular cells, contributing to the maintenance of the differentiated phenotype. In fact, it has been demonstrated that TTF-1 and PAX-8 are able to activate transcription from thyroglobulin and thyroperoxidase (TPO) promoters, the transcriptional activity of which is in vivo restricted only to the thyroid folli...
متن کاملSpecific Transcription Factors Prognostic for Prostate Cancer
We have previously identified (M. Wang et aL, OncoL Res., in press, 1998) an enhancer element [human tissue inhibitor of metalloproteinase-1 enhancer-i (HTE)] for the human tissue inhibitor of metalloproteinase-1 promoter that binds a novel zinc finger, cysteine-rich transcription factor (CRTF). In this study, we have used electrophoretic mobifity shift assays to examine the relative level of e...
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ژورنال
عنوان ژورنال: Endocrine Journal
سال: 1997
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.44.775